Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

Traumatic Brain Injury (TBI) remains a major cause of disability worldwide. It involves a
complex neurometabolic cascade, including oxidative stress. The products of this …

Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Oxidative stress (OS) and excessive reactive oxygen species (ROS) production have been
implicated in many neurological pathologies, including acute seizures and epilepsy. Seizure …

When many widely ingested foods are heated, a toxin called acrylamide (ACR) is created.
The aim of our research was to investigate if N acetylcysteine (NAC) and/or vitamin E (Vit E) …

The present investigation explores the potential of novel dual drug-loaded niosomes for
nasal delivery of Rivastigmine (RIV) and N-Acetyl Cysteine (NAC) to the brain. The dual …

Many epilepsies are acquired conditions following an insult to the brain such as a prolonged
seizure, traumatic brain injury or stroke. The generation of reactive oxygen species (ROS) …

Background Neurotoxicity is a major obstacle to the effectiveness of cisplatin (CDDP) in
cancer chemotherapy. Oxidative stress and inflammation are considered to be the major …

Mitochondria are dynamic organelles responsible for cellular energy production. Besides,
regulating energy homeostasis, mitochondria are responsible for calcium homeostasis …

Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with
the goal of providing more human‐like models for biopharmaceutical research. In this study …