The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Cardiovascular diseases (CVDs) are the leading cause of death globally, resulting in a
major health burden. Thus, an urgent need exists for exploring effective therapeutic targets …

Abundance of data on the role of inflammatory immune responses in the progression or
inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for …

Cell-cell communication is essential for tissue development, regeneration and function, and
its disruption can lead to diseases and developmental abnormalities. The revolution of …

Metabolite-associated cell communications play critical roles in maintaining the normal
biological function of human through coordinating cells, organs and physiological systems …

Aging is a complex phenomenon that causes the accumulation of cellular damage, leading
to an increased incidence of major age-related diseases such as cancer …

Results Progression of NAFLD and HCC are associated with remodeling of the hepatic
structural cells, fibroblasts and endothelial cells, associated with shifts from predominant T …

肝脏神经系统通过释放各种神经递质直接参与肝脏正常生理功能的调节, 对维持机体稳态至关
重要, 同时也参与了肝脏疾病的发生与发展过程, 本文主要综述神经调控在肝脏疾病发生发展中 …

The rapid onset of innate immune defenses is critical for early control of viral replication in
an infected host, yet it can also lead to irreversible tissue damage, especially in the …

Methods By utilizing multi-omics data, we investigated metabolic dysregulation in gastric
cancer and identified three distinct metabolic subtypes. Results These subtypes exhibited …