Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, B Zhang… - Molecular cancer, 2021 - Springer
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …
phenotypic and functional heterogeneity, are the most essential components of the tumor …
[HTML][HTML] Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming
Z Li, C Sun, Z Qin - Theranostics, 2021 - ncbi.nlm.nih.gov
Cancer cells are well-known for adapting their metabolism to maintain high proliferation
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
Metabolic codependencies in the tumor microenvironment
P Dey, AC Kimmelman, RA DePinho - Cancer Discovery, 2021 - AACR
Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …
Cancer-associated fibroblasts in tumor microenvironment–Accomplices in tumor malignancy
There is much cellular heterogeneity in the tumor microenvironment. The tumor epithelia
and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of …
and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of …
Reactive oxygen species: a volatile driver of field cancerization and metastasis
Field cancerization and metastasis are the leading causes for cancer recurrence and
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …
The roles of ROS in cancer heterogeneity and therapy
PL de Sá Junior, DAD Câmara… - Oxidative medicine …, 2017 - Wiley Online Library
Cancer comprises a group of heterogeneous diseases encompassing high rates of
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …
[HTML][HTML] The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy
Although survival outcomes of cancer patients have been improved dramatically via
conventional chemotherapy and targeted therapy over the last decades, there are still some …
conventional chemotherapy and targeted therapy over the last decades, there are still some …
The mitochondrion as an emerging therapeutic target in cancer
KG Roth, I Mambetsariev, P Kulkarni… - Trends in molecular …, 2020 - cell.com
Mitochondria have emerged as important pharmacological targets because of their key role
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …
Elucidating the metabolic plasticity of cancer: mitochondrial reprogramming and hybrid metabolic states
Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the
dominant metabolic phenotype in cancer cells for a long time. More recently, it has been …
dominant metabolic phenotype in cancer cells for a long time. More recently, it has been …
'Reverse Warburg effect'of cancer‑associated fibroblasts
L Liang, W Li, X Li, X Jin, Q Liao… - … Journal of Oncology, 2022 - spandidos-publications.com
Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …