Metabolic syndrome pathophysiology and predisposing factors

A Bovolini, J Garcia, MA Andrade… - International journal of …, 2021 - thieme-connect.com
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors with high prevalence
among adult populations and elevated costs for public health systems worldwide. Despite …

[HTML][HTML] Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction

JG Cho, A Lee, W Chang, MS Lee, J Kim - Frontiers in immunology, 2018 - frontiersin.org
Endothelial cells that line the inner walls of blood vessels are in direct contact with blood
and display remarkable heterogeneity in their response to exogenous stimuli. These ECs …

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

Y Li, C Chen, Y Ma, J Xiao, G Luo, Y Li, D Wu - Life sciences, 2019 - Elsevier
Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female
infertility around the world. It is no longer considered simply as a disease of ovary. Now …

The role of low-grade inflammation in the polycystic ovary syndrome

A Repaci, A Gambineri, R Pasquali - Molecular and cellular endocrinology, 2011 - Elsevier
PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …

Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions

L Pérez, N Muñoz-Durango, CA Riedel… - Cytokine & growth factor …, 2017 - Elsevier
During the last decade, the endothelial-to-mesenchymal transition (EndMT) process has
attracted considerable attention due to associations with the onset of certain diseases, such …

[HTML][HTML] Advanced glycation end products: a molecular target for vascular complications in diabetes

S Yamagishi, N Nakamura, M Suematsu, K Kaseda… - Molecular …, 2015 - Springer
A nonenzymatic reaction between reducing sugars and amino groups of proteins, lipids and
nucleic acids contributes to the aging of macromolecules and subsequently alters their …

Biological basis of depression in adults with diabetes

S Champaneri, GS Wand, SS Malhotra… - Current diabetes …, 2010 - Springer
Diabetes and depression are common comorbid conditions. Although certain health
behaviors and risk factors partially explain the association of depression and diabetes, other …

Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice

J Ketonen, J Shi, E Martonen, E Mervaala - Circulation Journal, 2010 - jstage.jst.go.jp
Background: Biological substances derived from perivascular fat modulate vascular tone,
thus alterations in periadventitial adipose tissue (PVAT) may aggravate endothelial …

The forgotten face of regular physical exercise: a 'natural'anti-atherogenic activity

J Szostak, P Laurant - Clinical science, 2011 - portlandpress.com
Humans are not programmed to be inactive. The combination of both accelerated sedentary
lifestyle and constant food availability disturbs ancient metabolic processes leading to …

Profiling of the three circulating monocyte subpopulations in human obesity

EF Devêvre, M Renovato-Martins… - The Journal of …, 2015 - journals.aai.org
Three subpopulations of circulating monocytes have been described: CD14 2+
CD16−(classical monocytes [CM]), CD14 2+ CD16+(intermediate monocytes [IM]), and …