In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

Acetylation of histones is a key post-translational modification that guides gene expression
regulation. In yeast, the class I histone deacetylase containing Rpd3S complex plays a …

The aging process has been one of the most necessary research fields in the current
century, and knowing different theories of aging and the role of different genetic, epigenetic …

Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It
has been proposed that these PTMs form localized 'codes' that are read by specialized …

The post-translational modifications of histone H4 play significant roles in regulation of
epigenetic status. Reconstituted nucleosomes that mimic the native chromatin are valuable …

Thioamides are naturally occurring isosteres of amide bonds in which the chalcogen atom of
the carbonyl is changed from oxygen to sulfur. This substitution gives rise to altered …

As a member of the histone deacetylase protein family, the NAD+-dependent SIRT6 plays
an important role in maintaining genomic stability and regulating cell metabolism …

Abstract Sirtuin 6 (SIRT6) is an NAD+-dependent histone H3 deacetylase that is prominently
found associated with chromatin, attenuates transcriptionally active promoters and regulates …

The sirtuins are NAD+‐dependent lysine deacylases, comprising seven isoforms (SIRT1–7)
in humans, which are involved in the regulation of a plethora of biological processes …

Although studies have shown that protein 53 (p53)-mediated ferroptosis is involved in acute
lung injury (ALI), the mechanism of its regulation remains unclear. The protective effects of …