[HTML][HTML] The contribution of extracellular vesicles from senescent endothelial and vascular smooth muscle cells to vascular calcification

C Mas-Bargues, C Borrás, M Alique - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Vascular calcification is an irreversible pathological process associated with a loss of
vascular wall function. This process occurs as a result of aging and age-related diseases …

[HTML][HTML] Endoplasmic reticulum stress and pathogenesis of vascular calcification

Z Rao, Y Zheng, L Xu, Z Wang, Y Zhou… - Frontiers in …, 2022 - frontiersin.org
Vascular calcification (VC) is characterized by calcium phosphate deposition in blood vessel
walls and is associated with many diseases, as well as increased cardiovascular morbidity …

Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization

G Su, D Zhang, T Li, T Pei, J Yang, S Tu, S Liu, J Ren… - Bone Research, 2023 - nature.com
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic
calcification and pathological calcified osteoarthritis and in wound repair of the skeletal …

The functional role of soluble proteins acquired by extracellular vesicles

AP Ramos, HG Sebinelli, P Ciancaglini… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer‐enclosed nanosized particles released by all
cell types during physiological as well as pathophysiological processes to carry out diverse …

Do Media Extracellular Vesicles and Extracellular Vesicles Bound to the Extracellular Matrix Represent Distinct Types of Vesicles?

S Mebarek, R Buchet, S Pikula, A Strzelecka-Kiliszek… - Biomolecules, 2023 - mdpi.com
Mineralization-competent cells, including hypertrophic chondrocytes, mature osteoblasts,
and osteogenic-differentiated smooth muscle cells secrete media extracellular vesicles …

Vascular calcification: from the perspective of crosstalk

S Yang, Z Zeng, Q Yuan, Q Chen, Z Wang, H Xie… - Molecular …, 2023 - Springer
Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and
mortality, but anti-VC treatment remains an area to be tackled due to the ill-defined …

The role and applications of extracellular vesicles in osteoporosis

F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone Research, 2024 - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …

Ectopic mineralization-inspired cell membrane-based matrix vesicle analogs for in-depth remineralization of dentinal tubules for treating dentin hypersensitivity

M Li, X Zheng, Z Dong, Y Zhang, W Wu, X Chen… - Nano Research, 2023 - Springer
The invasion of etched dentinal tubules (DTs) by external substances induces dentin
hypersensitivity (DH). The deep and compact occlusion of DTs is highly desirable for treating …

[HTML][HTML] Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 …

W Gao, K Gu, L Ma, F Yang, L Deng… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Phenotypic switching (from contractile to synthetic) of vascular smooth muscle cells (VSMCs)
is essential in the progression of atherosclerosis. The damaged endothelium in the …

[HTML][HTML] Unraveling the role of carboxylate groups and elastin particle size in medial calcification

T Son, M Cerruti - International Journal of Biological Macromolecules, 2024 - Elsevier
While it is known that calcium phosphate (CaP) minerals deposit in elastin-rich medial layers
of arteries during medial calcification, their nucleation and growth sites are still debated …