Plant-derived 5 α-reductase inhibitors, such as β-sitosterol and phytosterol glycosides, have
been used to treat androgenic alopecia, but their oral absolute bioavailability is poor. This …

Sorafenib (SRB), a multikinase inhibitor, is effective in reducing experimental corneal
neovascularization (CNV) after oral administration; however, its therapeutic use in ocular …

Many new chemical entities have limited water solubility and therefore show low and/or
variable oral bioavailability. Among the various strategies to overcome this challenge …

Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL)
and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high …

Tetramethylpyrazine (TMP) has low bioavailability due to its fast metabolism and short half-
life, which is not conducive to transdermal treatment of atopic dermatitis (AD). Therefore, in …

Preparation and characterization of novel functional nanostructured lipid carriers containing
β sitosterol has been studied. The nanostructured lipid carrires (NLCs) were formulated with …

Purpose. The current investigation is on the explicit development and evaluation of
nanostructured lipidic carriers (NLCs) through the oral route to overcome the inherent …

In the current research, the main focus was to overcome dermal delivery problems of
atorvastatin. To this end, atorvastatin solid lipid nanoparticles (ATR-SLNs) were prepared by …

Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness,
is critical to patients' outcomes. However, many orally administered therapeutic drugs are …

Background Nutraceuticals are food ingredients that provide benefits, since they are
considered to prevent chronic diseases and help improving health. However, utilization of …