The relationship between different dimensions of alcohol use and the burden of disease—an update

J Rehm, GE Gmel Sr, G Gmel, OSM Hasan, S Imtiaz… - …, 2017 - Wiley Online Library
Background and aims Alcohol use is a major contributor to injuries, mortality and the burden
of disease. This review updates knowledge on risk relations between dimensions of alcohol …

Cardiovascular risks and benefits of moderate and heavy alcohol consumption

J Fernandez-Sola - Nature Reviews Cardiology, 2015 - nature.com
The heart and vascular system are susceptible to the harmful effects of alcohol. Alcohol is an
active toxin that undergoes widespread diffusion throughout the body, causing multiple …

[HTML][HTML] The effects of ethanol on the heart: alcoholic cardiomyopathy

J Fernández-Solà - Nutrients, 2020 - mdpi.com
Alcoholic-dilated Cardiomyopathy (ACM) is the most prevalent form of ethanol-induced heart
damage. Ethanol induces ACM in a dose-dependent manner, independently of nutrition …

Cellular mechanisms of cardiomyopathy

PA Harvey, LA Leinwand - Journal of Cell Biology, 2011 - rupress.org
The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic
factors to maintain contractile function. When compensatory responses are not sustainable …

Alcoholic cardiomyopathy: pathophysiologic insights

MR Piano, SA Phillips - Cardiovascular toxicology, 2014 - Springer
Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in individuals with
a history of long-term heavy alcohol consumption. ACM is associated with a number of …

[HTML][HTML] Addressing the global burden of cardiovascular diseases; need for scalable and sustainable frameworks

S Mendis, I Graham, J Narula - Global Heart, 2022 - ncbi.nlm.nih.gov
Only 14 countries are on track to attain the Sustainable Development Goal (SDG) target of
reducing premature mortality from Noncommunicable Diseases (NCDs) by one-third by …

Alcoholic cardiomyopathy: a review

A George, VM Figueredo - Journal of cardiac failure, 2011 - Elsevier
Alcohol abuse can cause cardiomyopathy indistinguishable from other types of dilated
nonischemic cardiomyopathy. Most heavy drinkers remain asymptomatic in the earlier …

ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications

Y Zhang, J Ren - Pharmacology & therapeutics, 2011 - Elsevier
Alcoholic cardiomyopathy is manifested as cardiac hypertrophy, disrupted contractile
function and myofibrillary architecture. An ample amount of clinical and experimental …

Quantifying the contribution of alcohol to cardiomyopathy: a systematic review

J Rehm, OSM Hasan, S Imtiaz, M Neufeld - Alcohol, 2017 - Elsevier
Alcohol has a direct toxic impact on the heart, and while there is an ICD code for alcoholic
cardiomyopathy, the burden of alcohol-attributable cardiomyopathy is not clear. For the …

Light to moderate habitual alcohol consumption is associated with subclinical ventricular and left atrial mechanical dysfunction in an asymptomatic population: dose …

CL Hung, A Goncalves, YJ Lai, YH Lai, KT Sung… - Journal of the American …, 2016 - Elsevier
Background The effects of light to moderate alcohol consumption on cardiac mechanics
remain poorly understood. The aim of this study was to investigate the dose-response …