Promotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy

S Wei, W Hu, J Feng, Y Geng - Cell Communication and Signaling, 2022 - Springer
Abstract Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of
great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) …

Targeting TRIP13 for overcoming anticancer drug resistance

L Zhao, S Ye, S Jing, YJ Gao, T He - Oncology Reports, 2023 - spandidos-publications.com
Cancer is one of the greatest dangers to human wellbeing and survival. A key barrier to
effective cancer therapy is development of resistance to anti-cancer medications. In cancer …

DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in …

S Agarwal, F Afaq, P Bajpai, HG Kim… - Molecular …, 2022 - Wiley Online Library
Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is
upregulated in various human cancers, including colorectal cancer (CRC). This study …

TRIP13, identified as a hub gene of tumor progression, is the target of microRNA-4693-5p and a potential therapeutic target for colorectal cancer

Y Chen, D Chen, Y Qin, C Qiu, Y Zhou, M Dai, L Li… - Cell death …, 2022 - nature.com
Colorectal cancer (CRC) is one of the digestive tract malignancies whose early symptoms
are not obvious. This study aimed to identify novel targets for CRC therapy, especially early …

Upregulation of TRIP13 promotes the malignant progression of lung cancer via the EMT pathway

R Lu, Q Zhou, L Ju, L Chen, F Wang… - Oncology …, 2021 - spandidos-publications.com
Lung cancer is the most common malignant tumor type and it is associated with poor
prognosis. The identification of potential biomarkers is of great significance for the early …

microRNAs: Small molecules with a large impact on colorectal cancer

S Moazzendizaji, A Sevbitov, F Ezzatifar… - Biotechnology and …, 2022 - Wiley Online Library
Colorectal cancer (CRC) accounts for one of the main cancer‐related mortality and morbidity
worldwide. The molecular mechanisms of CRC development have been broadly …

BZW2 inhibition reduces colorectal cancer growth and metastasis

S Agarwal, F Afaq, P Bajpai, M Behring… - Molecular Cancer …, 2023 - aacrjournals.org
Because survival of patients with metastatic colorectal cancer remain poor, there is an
urgent need to identify potential novel druggable targets that are associated with colorectal …

[HTML][HTML] Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma

F Afaq, S Agarwal, P Bajpai, S Al Diffalha, HG Kim… - Neoplasia, 2024 - Elsevier
Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression,
but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the …

Phosphorylation of TRIP13 at Y56 induces radiation resistance but sensitizes head and neck cancer to cetuximab

R Banerjee, M Liu, E Bellile, LB Schmitd, M Goto… - Molecular Therapy, 2022 - cell.com
Radiation therapy, a mainstay of treatment for head and neck cancer, is not always curative
due to the development of treatment resistance; additionally, multi-institutional trials have …

TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4

X Liu, X Shen, J Zhang - Environmental Toxicology, 2021 - Wiley Online Library
Increasing evidence has indicated that thyroid hormone receptor interacting protein 13
(TRIP13) exerts a cancer‐promoting role in a broad spectrum of cancers. However, the …