Promotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy
S Wei, W Hu, J Feng, Y Geng - Cell Communication and Signaling, 2022 - Springer
Abstract Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of
great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) …
great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) …
Targeting TRIP13 for overcoming anticancer drug resistance
L Zhao, S Ye, S Jing, YJ Gao, T He - Oncology Reports, 2023 - spandidos-publications.com
Cancer is one of the greatest dangers to human wellbeing and survival. A key barrier to
effective cancer therapy is development of resistance to anti-cancer medications. In cancer …
effective cancer therapy is development of resistance to anti-cancer medications. In cancer …
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in …
Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is
upregulated in various human cancers, including colorectal cancer (CRC). This study …
upregulated in various human cancers, including colorectal cancer (CRC). This study …
TRIP13, identified as a hub gene of tumor progression, is the target of microRNA-4693-5p and a potential therapeutic target for colorectal cancer
Y Chen, D Chen, Y Qin, C Qiu, Y Zhou, M Dai, L Li… - Cell death …, 2022 - nature.com
Colorectal cancer (CRC) is one of the digestive tract malignancies whose early symptoms
are not obvious. This study aimed to identify novel targets for CRC therapy, especially early …
are not obvious. This study aimed to identify novel targets for CRC therapy, especially early …
Upregulation of TRIP13 promotes the malignant progression of lung cancer via the EMT pathway
R Lu, Q Zhou, L Ju, L Chen, F Wang… - Oncology …, 2021 - spandidos-publications.com
Lung cancer is the most common malignant tumor type and it is associated with poor
prognosis. The identification of potential biomarkers is of great significance for the early …
prognosis. The identification of potential biomarkers is of great significance for the early …
microRNAs: Small molecules with a large impact on colorectal cancer
S Moazzendizaji, A Sevbitov, F Ezzatifar… - Biotechnology and …, 2022 - Wiley Online Library
Colorectal cancer (CRC) accounts for one of the main cancer‐related mortality and morbidity
worldwide. The molecular mechanisms of CRC development have been broadly …
worldwide. The molecular mechanisms of CRC development have been broadly …
BZW2 inhibition reduces colorectal cancer growth and metastasis
Because survival of patients with metastatic colorectal cancer remain poor, there is an
urgent need to identify potential novel druggable targets that are associated with colorectal …
urgent need to identify potential novel druggable targets that are associated with colorectal …
[HTML][HTML] Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
F Afaq, S Agarwal, P Bajpai, S Al Diffalha, HG Kim… - Neoplasia, 2024 - Elsevier
Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression,
but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the …
but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the …
Phosphorylation of TRIP13 at Y56 induces radiation resistance but sensitizes head and neck cancer to cetuximab
R Banerjee, M Liu, E Bellile, LB Schmitd, M Goto… - Molecular Therapy, 2022 - cell.com
Radiation therapy, a mainstay of treatment for head and neck cancer, is not always curative
due to the development of treatment resistance; additionally, multi-institutional trials have …
due to the development of treatment resistance; additionally, multi-institutional trials have …
TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4
X Liu, X Shen, J Zhang - Environmental Toxicology, 2021 - Wiley Online Library
Increasing evidence has indicated that thyroid hormone receptor interacting protein 13
(TRIP13) exerts a cancer‐promoting role in a broad spectrum of cancers. However, the …
(TRIP13) exerts a cancer‐promoting role in a broad spectrum of cancers. However, the …