ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …

Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

One of the imperative medical requirements for cancer treatment is how to establish an
imaging‐guided nanocarrier that combines therapeutic and imaging agents into one system …

Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor
prognosis can be attributed to both troublesome detections at the initial stage, which makes …

Abstract Recently, United States Food and Drug Administration (FDA) and European
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …

RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …

In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug
delivery systems are based on the difference between cancer and healthy cells. Currently …

RRM2, the small subunit of ribonucleotide reductase, is identified as a tumor promotor and
therapeutic target. It is common to see the overexpression of RRM2 in chemo-resistant …

Efficient endosomal escape is the most essential but challenging issue for siRNA drug
development. Herein, a series of quaternary ammonium-based amphiphilic triblock …

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel,
docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy …