The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

The cardiovascular complications contribute to a majority of diabetes associated morbidity
and mortality, accounting for 44% of death in those patients with type 1 diabetes mellitus …

Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-
resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is
symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory …

The energetic burden of continuously concentrating solutes against gradients along the
tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) …

The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Diabetes mellitus is currently a major public health problem. A common complication of
diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads …

In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy,
and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal …

Oxidative stress plays a pivotal role in the development of diabetes complications, both
microvascular and cardiovascular. The metabolic abnormalities of diabetes cause …