Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

Topical drug delivery to the posterior segment of the eye

M Loescher, C Seiz, J Hurst, S Schnichels - Pharmaceutics, 2022 - mdpi.com
Topical drug delivery to the posterior segment of the eye is a very complex challenge.
However, topical delivery is highly desired, to achieve an easy-to-use treatment option for …

Deep learning-based glaucoma detection with cropped optic cup and disc and blood vessel segmentation

MT Islam, ST Mashfu, A Faisal, SC Siam… - Ieee …, 2021 - ieeexplore.ieee.org
Glaucoma is an irreversible neurodegenerative disease, where intraocular hypertension is
developed due to the increased aqueous humor and blockage of the drainage system …

The intertwined roles of oxidative stress and endoplasmic reticulum stress in glaucoma

DJ Hurley, C Normile, M Irnaten, C O'Brien - Antioxidants, 2022 - mdpi.com
Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

Microfluidic Separation and Enrichment of Escherichia coli by Size Using Viscoelastic Flows

T Zhang, AK Cain, L Semenec, L Liu… - Analytical …, 2023 - ACS Publications
Here, we achieve the separation and enrichment of Escherichia coli clusters from its singlets
in a viscoelastic microfluidic device. E. coli, an important prokaryotic model organism and a …

Novel therapies for the prevention of fibrosis in glaucoma filtration surgery

CG Shao, NR Sinha, RR Mohan, AD Webel - Biomedicines, 2023 - mdpi.com
Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration
surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but …

Primary open angle glaucoma prevalence in Europe: a systematic review and meta-analysis

GG Afflitto, F Aiello, M Cesareo, C Nucci - Journal of Glaucoma, 2022 - journals.lww.com
Purpose: This study aimed to evaluate the prevalence of POAG in Europe. Methods: Two
authors independently conducted a systematic literature search on PubMed/MedLine, Web …

The dual effect of Rho-kinase inhibition on trabecular meshwork cells cytoskeleton and extracellular matrix in an in vitro model of glaucoma

J Buffault, F Brignole-Baudouin, É Reboussin… - Journal of Clinical …, 2022 - mdpi.com
The trabecular meshwork (TM) is the main site of drainage of the aqueous humor, and its
dysfunction leads to intraocular pressure elevation, which is one of the main risk factors of …

Immunomodulatory and antioxidant drugs in glaucoma treatment

F Buonfiglio, N Pfeiffer, A Gericke - Pharmaceuticals, 2023 - mdpi.com
Glaucoma, a group of diseases characterized by progressive retinal ganglion cell loss,
cupping of the optic disc, and a typical pattern of visual field defects, is a leading cause of …

Glaucoma and systemic disease

E Hsu, M Desai - Life, 2023 - mdpi.com
Glaucoma is the leading cause of irreversible blindness in the world. Due to its potential to
cause permanent vision loss, it is important to understand how systemic conditions and their …