Clinical practice guideline recommendations on tapering and discontinuing antidepressants for depression: a systematic review

A Sørensen, K Juhl Jørgensen… - Therapeutic advances …, 2022 - journals.sagepub.com
Background: Tapering and discontinuing antidepressants are important aspects of the
management of patients with depression and should therefore be considered in clinical …

Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis

J Henssler, Y Schmidt, U Schmidt, G Schwarzer… - The Lancet …, 2024 - thelancet.com
Background Antidepressant discontinuation symptoms are becoming an increasingly
important part of clinical practice, but the incidence of antidepressant discontinuation …

Withdrawal syndrome following discontinuation of 28 antidepressants: pharmacovigilance analysis of 31,688 reports from the WHO spontaneous reporting database

C Gastaldon, G Schoretsanitis, E Arzenton, E Raschi… - Drug Safety, 2022 - Springer
Introduction Evidence is lacking on withdrawal syndrome related to individual
antidepressants and relevant risk factors for severe reactions. Objective To ascertain …

RELEASE (REdressing Long-tErm Antidepressant uSE): protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 …

KA Wallis, M Donald, M Horowitz, J Moncrieff, RS Ware… - Trials, 2023 - Springer
Background Many people experience withdrawal symptoms when they attempt to stop
antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing …

Outcomes of hyperbolic tapering of antidepressants

J van Os, PC Groot - Therapeutic advances in …, 2023 - journals.sagepub.com
Background: In patients attempting to discontinue their antidepressant medication, there
have been no prospective studies on patterns of withdrawal as a function of the rate of …

[HTML][HTML] Designing withdrawal support services for antidepressant users: patients' views on existing services and what they really need

J Read, J Moncrieff, MA Horowitz - Journal of Psychiatric Research, 2023 - Elsevier
Abstract Background Public Health England has recommended that services be put in place
to support people who choose to withdraw from antidepressants because of a current gap …

Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression

D Erritzoe, T Barba, MJ Spriggs… - Journal of …, 2024 - journals.sagepub.com
Background: There is growing evidence for the therapeutic effects of the psychedelic drug
psilocybin for major depression. However, due to the lack of safety data on combining …

Acceptability and optimisation of resources to support antidepressant cessation: a qualitative think-aloud study with patients in Australian primary care

S McDonald, K Wallis, M Horowitz, E Mann, V Le… - British Journal of …, 2024 - bjgp.org
Background Stopping long-term (> 12 months) antidepressant use can be difficult due to
unpleasant withdrawal symptoms. Many people do not recognise withdrawal symptoms or …

Current strategies for tapering psychiatric drugs: differing recommendations, impractical doses, and other barriers

JK Eserian, VP Blanco, LP Mercuri… - Psychiatry …, 2023 - Elsevier
While effective ways to prevent withdrawal symptoms from psychiatric drugs remain unclear,
a highly accepted clinical approach for treatment discontinuation is to gradually reduce …

'We need more support and doctors that understand the process of tapering…': A content analysis of free‐text responses to a questionnaire on discontinuing long‐term …

T Lynch, C Ryan, C Huff, DE Foster… - Health …, 2024 - Wiley Online Library
Background Many individuals worldwide continue to take benzodiazepine receptor agonists
(BZRAs) long term (≥ 3 months). The aim of this study was to conduct a content analysis of …