Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in
the regulation of many complex physiological processes in humans. Abnormal ER signaling …

By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ
exert opposite effects on cellular processes that include proliferation, apoptosis and …

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

BACKGROUND & AIMS: Smoking has been implicated in many malignant diseases, but its
association with colorectal cancer (CRC) is controversial. We quantitatively evaluated the …

Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of
estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals …

It recently has been recognized that men develop colonic adenomas and carcinomas at an
earlier age and at a higher rate than women. In the Apc Pirc/+(Pirc) rat model of early colonic …

Tissue inflammation is a tightly regulated process that normally serves to recruit the immune
system to sites of infection and injury and to facilitate tissue repair processes. When an …