Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging

CL Chapman, BD Johnson, MD Parker, D Hostler… - Temperature, 2021 - Taylor & Francis
The kidneys' integrative responses to heat stress aid thermoregulation, cardiovascular
control, and water and electrolyte regulation. Recent evidence suggests the kidneys are at …

The potential for renal injury elicited by physical work in the heat

ZJ Schlader, D Hostler, MD Parker, RR Pryor, JW Lohr… - Nutrients, 2019 - mdpi.com
An epidemic of chronic kidney disease (CKD) is occurring in laborers who undertake
physical work in hot conditions. Rodent data indicate that heat exposure causes kidney …

Single-cell RNA sequencing reveals renal endothelium heterogeneity and metabolic adaptation to water deprivation

SJ Dumas, E Meta, M Borri, J Goveia… - Journal of the …, 2020 - journals.lww.com
Background Renal endothelial cells from glomerular, cortical, and medullary kidney
compartments are exposed to different microenvironmental conditions and support specific …

GDF15 plasma level is inversely associated with level of physical activity and correlates with markers of inflammation and muscle weakness

M Conte, M Martucci, G Mosconi, A Chiariello… - Frontiers in …, 2020 - frontiersin.org
Growth differentiation factor 15 (GDF15) is a stress molecule produced in response to
mitochondrial, metabolic and inflammatory stress with a number of beneficial effects on …

[HTML][HTML] Soft drink consumption during and following exercise in the heat elevates biomarkers of acute kidney injury

CL Chapman, BD Johnson… - American Journal …, 2019 - journals.physiology.org
The purpose of this study was to test the hypothesis that consuming a soft drink (ie, a high-
fructose, caffeinated beverage) during and following exercise in the heat elevates …

Occupational heat exposure and the risk of chronic kidney disease of nontraditional origin in the United States

CL Chapman, HW Hess, RAI Lucas… - American Journal …, 2021 - journals.physiology.org
Occupational heat exposure is linked to the development of kidney injury and disease in
individuals who frequently perform physically demanding work in the heat. For instance, in …

External workload indicators of muscle and kidney mechanical injury in endurance trail running

D Rojas-Valverde, B Sánchez-Ureña… - International Journal of …, 2019 - mdpi.com
Muscle and kidney injury in endurance athletes is worrying for health, and its relationship
with physical external workload (eWL) needs to be explored. This study aimed to analyze …

Exertional rhabdomyolysis and acute kidney injury in endurance sports: a systematic review

D Rojas-Valverde, B Sánchez-Ureña… - European journal of …, 2021 - Taylor & Francis
The increase of wide-spread participation in endurance events in sports such as open water
swimming, cycling, running and triathlons, has given rise to a concern about potential …

Changes in novel AKI biomarkers after exercise. A systematic review

W Wołyniec, W Ratkowski, J Renke… - International Journal of …, 2020 - mdpi.com
More than 100 substances have been identified as biomarkers of acute kidney injury. These
markers can help to diagnose acute kidney injury (AKI) in its early phase, when the …

Exercise-related hemoconcentration and hemodilution in hydrated and dehydrated athletes: An observational study of the Hungarian canoeists

Z Komka, B Szilágyi, D Molnár, B Sipos, M Tóth… - Plos One, 2022 - journals.plos.org
Hemoconcentration during exercise is a well-known phenomenon, however, the extent to
which dehydration is involved is unclear. In our study, the effect of dehydration on exercise …