Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …

Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-
risk disease. Here, we used a three-platform sequencing approach, including whole …

Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

PURPOSE: Historically, cancer predisposition syndromes (CPSs) were rarely established for
children with cancer. This nationwide, population-based study investigated how frequently …

Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Background Genetic predisposition is has been identified as a cause of cancer, yet little is
known about the role of adult cancer predisposition syndromes in childhood cancer. We …

As the understanding of the genetic etiology of childhood cancers increases, the need for
the involvement of experts familiar with the provision of genetic counseling for this …

Patients with DICER1 predisposition syndrome have an increased risk to develop
pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, and several …