OBJECTIVE: To evaluate the biologic activity of multiple intravitreal injections of ranibizumab
in patients with center-involving clinically significant diabetic macular edema (DME) and to …

Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

Abstract Five member heterocyclic 1, 3, 4-oxadiazole nucleus find unique place in medicinal
chemistry and plays significant role in producing anticancer activity. The small and simple 1 …

Angiogenesis is a crucial event for tumor growth and it is regulated predominantly by several
different growth factors. Vascular endothelial growth factor protein family (VEGF) and its …

Intraocular delivery of anti-vascular endothelial growth factor (VEGF) therapies is now used
widely to treat age-related macular degeneration, and is currently undergoing evaluation in …

Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety
of cells to regulate diverse biological responses. The VEGF-A family member promotes …

Members of the vascular endothelial growth factor (VEGF) family are crucial regulators of
neovascularization and are classified as cystine knot growth factors that specifically bind …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

Blood vessels respond to changes in mechanical load from circulating blood in the form of
shear stress and mechanical strain as the result of heart propulsions by changes in …

Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …