Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Many cancer therapies produce toxic side effects whose molecular mechanisms await full
elucidation. The most feared and studied side effect of chemotherapeutic drugs is …

Annotating the molecular basis of human disease remains an unsolved challenge, as 93%
of disease loci are non-coding and gene-regulatory annotations are highly incomplete …

Despite widespread use of statins to reduce low-density lipoprotein cholesterol (LDL-C) and
associated atherosclerotic cardiovascular risk, many patients do not achieve sufficient LDL …

Many patients do not achieve optimal low-density lipoprotein cholesterol (LDL-C) levels with
statins alone; others are unable to tolerate statin therapy. Additional non-statin treatment …

Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …

5′-Adenosine monophosphate–activated protein kinase (AMPK) is a master regulator of
energy homeostasis in eukaryotes. Despite three decades of investigation, the biological …

AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy
balance by sensing and responding to increases in AMP/ADP concentration relative to ATP …

Glycogen is a branched polymer of glucose that acts as a store of energy in times of
nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of …