Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5′-
triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves …

Elevated blood pressure is a key risk factor for developing cardiovascular diseases. Blood
pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are …

Under various pathological conditions, including thrombosis and inflammation, extracellular
nucleotide levels may increase because of both active release and passive leakage from …

Cholesterol is a key component of cell membranes with a proven modulatory role on the
function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

The purinergic signalling system, which utilises ATP, related nucleotides and adenosine as
transmitter molecules, appeared very early in evolution: release mechanisms and ATP …

Adenosine is an endogenous nucleoside with a short half-life that regulates many
physiological functions involving the heart and cardiovascular system. Among the …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …