Sickle cell anemia (SCA) is a hemoglobinopathy characterized by hemolysis and vaso-
occlusions caused by rigidly distorted red blood cells. Sickle cell crisis is associated with …

The SMC s of skeletal muscle arterioles are intricately sensitive to changes in membrane
potential. Upon increasing luminal pressure, the SMC s depolarize, thereby opening VDCC …

Background: Several studies have reported the beneficial effects of anti-platelet drugs in
cardioprotection against ischaemia–reperfusion injuries. To date, no studies have focused …

Purine nucleosides (adenosine) and nucleotides such as adenosine mono/di/triphosphate
(AMP/ADP/ATP) may produce complex cardiovascular responses. For example, adenosine …

Chronic inflammation is the hallmark of cardiovascular pathologies with a major role in both
disease progression and occurrence of long-term complications. The massive release of …

Calcitonin gene-related peptide (CGRP), an endogenous neuropeptide released from
perivascular sensory nerves, exerts a powerful vasodilatation. Interestingly, adenosine …

This tribute article presents selected immunocytochemical and transmission electron
microscope data on the location of ATP-gated P2X receptor in the rat brain, as studied in the …

Arterial medial calcification (AMC) has been associated with phenotypic changes in vascular
smooth muscle cells (VSMCs) that reportedly makes them more osteoblast-like. Previous …

Background: In preclinical models, the pannexin-1 channel has been shown to be involved
in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 …

Background and aim Adenosine is believed to play an important role in local acupuncture
analgesia. The aim of this study was to investigate the contribution of adenosine to the …