This review is focused on the pathophysiology and therapeutic potential of purinergic
signalling. A wide range of diseases are considered, including those of the central nervous …

Etiology of the Alzheimer's disease (AD) is not fully understood. Different pathological
processes are considered, such as amyloid deposition, tau protein phosphorylation …

The P2X7 receptor (P2X7R) possesses a unique structure associated to an as yet not fully
understood mechanism of action that facilitates cell permeability to large ionic molecules …

There is long-term (trophic) purinergic signalling involving cell proliferation, differentiation,
motility and death in the development and regeneration of most systems of the body, in …

Diabetes mellitus (DM) and hypertension are highly prevalent worldwide health problems
and frequently associated with severe clinical complications, such as diabetic …

Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …

Within the family of purinergic receptors, the P2X1 receptor is a ligand-gated ion channel
that plays a role in urogenital, immune and cardiovascular function. Specifically, the P2X1 …

Breast cancer is currently the most common cancer and the leading cause of cancer death
among women worldwide. Advanced breast cancer is prone to metastasis, and there is …

There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled …

Background: bone tissue regeneration remains a current challenge. A growing body of
evidence shows that mitochondrial dysfunction impairs osteogenesis and that this organelle …