The P2 purinergic receptor family implicated in many physiological processes, including
neurotransmission, mechanical adaptation and inflammation, consists of ATP-gated non …

When species are continuously distributed across environmental gradients, the relative
strength of selection and gene flow shape spatial patterns of genetic variation, potentially …

There is a long-lasting controversy surrounding an association between abacavir (ABC) and
an increased risk of cardiovascular disease in HIV-positive patients. Although differing in …

Rationale: Purinergic signaling plays an important role in inflammation and vascular
integrity, but little is known about purinergic mechanisms during the pathogenesis of …

Objective—Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a
major regulator of arteriolar vasoconstriction, vascular resistance, and blood pressure …

Background and Purpose P2Y12 receptors regulate different forms of pain and
inflammation. In this study, we investigated the participation of P2Y12 receptors in an animal …

Epilepsy is one of the most common chronic diseases of the central nervous system (CNS).
Treatment of epilepsy remains, however, a clinical challenge with over 30% of patients not …

ATP, norepinephrine and NPY are co-released by sympathetic nerves innervating arteries.
ATP elicits vasoconstriction via activation of smooth muscle P2X receptors. The functional …

There is abundant evidence that ATP (adenosine 5′-triphosphate) is released from a
variety of cultured cells in response to mechanical stimulation. The release mechanism …

Neuropeptide Y (NPY) is co-released with norepinephrine and ATP by sympathetic nerves
innervating arteries. Circulating NPY is elevated during exercise and cardiovascular …