Pituitary adenylate cyclase-activating polypeptide (PACAP) was first identified in
hypothalamus, based on its ability to elevate cyclic AMP in the anterior pituitary. PACAP has …

Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal
mineralization and has been associated with the transdifferentiation of vascular smooth …

The anoxemia theory proposes that an imbalance between the demand for and supply of
oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now …

In the last years, it has become evident that both acute and chronic physical exercise trigger
responses/adaptations in the purinergic signaling and these adaptations can be considered …

The objective was to evaluate the effect of photobiomodulation (PBM) using 980 nm diode
laser therapy (0.60 W, 0.77 W cm− 2, 36 J, 46 J cm− 2, 60 s) irradiated in continuous wave …

Under physiological conditions, peripheral arteries release endogenous vascular-protective
and antithrombotic agents. Endothelial cells actively synthesize vasoactive mediators, which …

Hypoxia-induced vascular endothelial dysfunction (VED) is a significant contributor to
several severe human diseases, including heart disease, stroke, dementia, and cancer …

Inflammation exerts a crucial pathogenic role in the development of hypertension. Hence,
the aim of the present study was to investigate the effects of ginger (Zingiber officinale) and …

Extracellular ATP activates inflammasome and triggers the release of multiple cytokines in
various immune cells, a process primarily mediated by P2X7 receptors. However, the …

Uridine adenosine tetraphosphate (Up 4 A), biosynthesized by activation of vascular
endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium …