P2X receptors are trimeric ATP-gated cation channels involved in diverse physiological
processes, ranging from muscle contraction to nociception. Despite the recent structure …

Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 10%
of people over the age of 65. Age is the greatest risk factor for AD, although a combination of …

Cerebrovascular dysfunction is a critical risk factor for the pathogenesis of Alzheimer's
disease (AD). The purinergic P2Y2 receptor and endoplasmic reticulum (ER) stress are …

This review considers the expression and roles of P2X receptors in the cardiovascular
system in health and disease and their potential as therapeutic targets. P2X receptors are …

Cell surface expression of specific receptors and ecto-nucleotidases makes extracellular
nucleotides such as ATP, ADP, UTP, and adenosine suitable as signaling molecules for …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by three major histopathological markers: amyloid-β (Aβ) plaques, neurofibrillary tangles …

Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

Introduction Hypoxia induces dilatation of the umbilical vein by releasing autocoids from
endothelium; prostaglandins (PGs), adenosine and nitric oxide (NO) have been implicated …

The activation of purinergic receptors by nucleotides and/or nucleosides plays an important
role in the control of vascular function, including modulation of vascular smooth muscle …

Endothelial cells release ATP in response to fluid shear stress, which activates purinergic
(P2) receptor-mediated signaling molecules including endothelial nitric oxide (eNOS), a …