The role of the purinergic signal has been extensively investigated in many tissues and
related organs, including the central and peripheral nervous systems as well as the …

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known
about their cardiovascular actions. The P2Y 14 receptor is a G i/o-coupled receptor which is …

Lewisite (LEW) is an arsenical vesicant that can be a potentially dangerous chemical
warfare agent (CWA). Eyes are particularly susceptible to vesicant induced injuries and …

Extracellular ATP and other nucleotides induce autocrine and/or paracrine purinergic
signalling via activation of the P2 receptors on the cell surface, which represents one of the …

Simple Summary Duchenne muscular dystrophy is a devastating disease that results from
mutations in the dystrophin gene (DMD) and can lead to heart and respiratory failure …

Etiopathogenesis of migraine involves different structures of the central nervous system: the
trigeminal nerve with nuclei located in the brain stem, vascular system, and the cerebral …

Background An area of ongoing controversy is the role adenosine to regulate vascular tone
in conduit vessels that regulate compliance, and the role of nitric oxide (NO), potassium …

Extracellular pyrimidines activate P2Y receptors on both smooth muscle cells and
endothelial cells, leading to vasoconstriction and relaxation respectively. The aim of this …

Red blood cells (RBCs) exhibit an interesting response to hydrodynamic flow, releasing
adenosine triphosphate (ATP). Subsequently, these liberated ATP molecules initiate a …

The role of hyperhomocysteinemia in coronary artery disease (CAD) patients remains
unclear. The present study evaluated the relationship between homocysteine (HCys) …