Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer

L Kooshki, P Mahdavi, S Fakhri, EK Akkol, H Khan - Biofactors, 2022 - Wiley Online Library
Anticancer drugs are not purely effective because of their toxicity, side effects, high cost,
inaccessibility, and associated resistance. On the other hand, cancer is a complex public …

Ferulic acid: a natural phenol that inhibits neoplastic events through modulation of oncogenic signaling

H Singh Tuli, A Kumar, S Ramniwas, R Coudhary… - Molecules, 2022 - mdpi.com
Despite the immense therapeutic advances in the field of health sciences, cancer is still to
be found among the global leading causes of morbidity and mortality. Ethnomedicinally …

Role of natural products in developing novel anticancer agents: A perspective

BB Shaik, NK Katari… - Chemistry & …, 2022 - Wiley Online Library
Cancer is a heterogeneous disease and is one of the significant health issues, especially in
public health systems around the world. Natural products and their structural derivatives with …

Application of Box-Behnken design for optimization of phenolics extraction from Leontodon hispidulus in relation to its antioxidant, anti-inflammatory and cytotoxic …

NM Abd-El-Aziz, MS Hifnawy, AA El-Ashmawy… - Scientific Reports, 2022 - nature.com
To the best of our knowledge, there have been no phytochemical studies concerning the
wild plant Leontodon hispidulus Boiss.(Asteraceae). Optimization of the green extraction …

Therapeutic targeting of regulated signaling pathways of non-small cell lung carcinoma

GM Hasan, MI Hassan, SS Sohal, A Shamsi… - ACS omega, 2023 - ACS Publications
Non-small cell lung carcinoma (NSCLC) is the most common cancer globally.
Phytochemicals and small molecule inhibitors significantly prevent varying types of cancers …

Fungal endophytes: an accessible source of bioactive compounds with potential anticancer activity

N Rai, P Gupta, PK Keshri, A Verma, P Mishra… - Applied Biochemistry …, 2022 - Springer
Endophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host
plants without showing any immediate negative effects on them. Among numerous natural …

Anti-cancer effect of Rumex obtusifolius in combination with arginase/nitric oxide synthase inhibitors via downregulation of oxidative stress, inflammation, and …

M Ginovyan, H Javrushyan, G Petrosyan… - … International Journal of …, 2023 - Elsevier
Cancer continues to be a leading cause of death worldwide, making the development of
new treatment methods crucial in the fight against it. With cancer incidence rates increasing …

Synthesis, solvent-solute interactions (polar and non-polar), spectroscopic insights, topological aspects, Fukui functions, molecular docking, ADME, and donor …

AR Kumar, S Selvaraj, GPS Mol, M Selvaraj… - Journal of Molecular …, 2024 - Elsevier
The favorite heteroatom-containing compound, 2-(trifluoromethyl) benzimidazole (2TFMBI),
was synthesized and experimentally characterized using spectroscopic techniques. Density …

Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions

S Ramli, MS Sim, RM Guad, SCB Gopinath… - Journal of …, 2021 - Wiley Online Library
The rising trend of gastrointestinal (GI) cancer has become a global burden due to its
aggressive nature and poor prognosis. Long noncoding RNAs (lncRNAs) have recently …

Natural nutraceuticals, especially functional foods, their ma-jor bioactive components, formulation, and health benefits for disease prevention-An overview

CG Awuchi, COR Okpala - Journal of Food Bioactives, 2022 - isnff-jfb.com
Nutraceuticals play wide range of important roles, from health promotion, increasing life
expectancy, maintaining body cell integrity, to reducing the risks of many diseases. As …