Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the
United States. BZDs are a class of psychoactive drugs known for their depressant effect on …

Background Benzodiazepine misuse is a growing public health problem, with increases in
benzodiazepine-related overdose deaths and emergency room visits in recent years …

Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

Chronic insomnia is defined by difficulties in falling asleep, maintaining sleep, and early
morning awakening, and is coupled with daytime consequences such as fatigue, attention …

All classes of drug that are prescribed to treat depression are associated with withdrawal
syndromes. SSRI withdrawal syndrome occurs often and can be severe, and might compel …

Purpose Insomnia is problematic for older adults. After behavioral modifications fail to show
adequate response, pharmacologic options are used. The pharmacokinetics of agents used …

Purpose A Pan-Canadian Practice Guideline on Screening, Assessment, and Care of
Psychosocial Distress (Depression, Anxiety) in Adults With Cancer was identified for …

Benzodiazepines are some of the most commonly prescribed medications in the world.
These sedative-hypnotics can provide rapid relief for symptoms like anxiety and insomnia …

Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …