The airway epithelium in asthma

BN Lambrecht, H Hammad - Nature medicine, 2012 - nature.com
Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

The airway epithelium: soldier in the fight against respiratory viruses

M Vareille, E Kieninger, MR Edwards… - Clinical microbiology …, 2011 - Am Soc Microbiol
The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Lung megakaryocytes are immune modulatory cells

DN Pariser, ZT Hilt, SK Ture… - The Journal of …, 2021 - Am Soc Clin Investig
Although platelets are the cellular mediators of thrombosis, they are also immune cells.
Platelets interact both directly and indirectly with immune cells, impacting their activation and …

The sentinel role of the airway epithelium in asthma pathogenesis

ST Holgate - Immunological reviews, 2011 - Wiley Online Library
The adoption of the concept that asthma is primarily a disease most frequently associated
with elaboration of T‐helper 2 (Th2)‐type inflammation has led to the widely held concept …

[PDF][PDF] Biology of lung dendritic cells at the origin of asthma

BN Lambrecht, H Hammad - Immunity, 2009 - cell.com
Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to
inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining …

Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma

AS Feldman, Y He, ML Moore… - American journal of …, 2015 - atsjournals.org
A first step in primary disease prevention is identifying common, modifiable risk factors that
contribute to a significant proportion of disease development. Infant respiratory viral infection …

The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis

ST Holgate, G Roberts, HS Arshad… - Proceedings of the …, 2009 - atsjournals.org
Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern.
Because of this, most research has focused on investigating the role of allergic pathways …

Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis

O Krysko, G Holtappels, N Zhang, M Kubica… - Allergy, 2011 - Wiley Online Library
To cite this article: Krysko O, Holtappels G, Zhang N, Kubica M, Deswarte K, Derycke L,
Claeys S, Hammad H, Brusselle GG, Vandenabeele P, Krysko DV, Bachert C. Alternatively …

Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation

EO Gubernatorova, EA Gorshkova… - Frontiers in …, 2018 - frontiersin.org
Asthma is a common inflammatory disease of the airway caused by a combination of genetic
and environmental factors and characterized by airflow obstruction, wheezing, eosinophilia …

Effects of mesenchymal stem cells from human induced pluripotent stem cells on differentiation, maturation, and function of dendritic cells

WX Gao, YQ Sun, J Shi, CL Li, SB Fang… - Stem cell research & …, 2017 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have potent immunomodulatory
effects on multiple immune cells and have great potential in treating immune disorders …