Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells

E Meedt, D Weber, A Bonifacius… - Clinical Infectious …, 2023 - academic.oup.com
We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-
year-old female patient treated with third-party EBV-specific T cells followed by allogeneic …

[HTML][HTML] Characterization of a cytomegalovirus-specific T lymphocyte product obtained through a rapid and scalable production process for use in adoptive …

M Grau-Vorster, M López-Montañés, E Cantó… - Frontiers in …, 2020 - frontiersin.org
Immunosuppressed patients are susceptible to virus reactivation or de novo infection.
Adoptive immunotherapy, based on virus-specific T lymphocytes (VST), can prevent or treat …

[HTML][HTML] Broad and Efficient Activation of Memory CD4+ T Cells by Novel HAdV- and HCMV-Derived Peptide Pools

A Höttler, L März, M Lübke, HG Rammensee… - Frontiers in …, 2021 - frontiersin.org
Reactivation of Human Cytomegalovirus (HCMV) and Human Adenovirus (HAdV) in
immunocompromised patients following stem cell transplantation (SCT) or solid organ …

[HTML][HTML] Variances in antiviral memory T-Cell repertoire of CD45RA-and CD62L-Depleted lymphocyte products reflect the need of individual T-Cell selection strategies …

C Mangare, S Tischer-Zimmermann… - Transfusion Medicine …, 2022 - karger.com
Introduction: Viral infections and reactivations still remain a cause of morbidity and mortality
after hematopoietic stem cell transplantation due to immunodeficiency and …

Adoptive transfer of cellular immunity against cytomegalovirus by virus-specific lymphocytes from a third-party family donor

M Lindemann, B Eiz-Vesper, NK Steckel… - Bone Marrow …, 2018 - nature.com
Infection remains a major challenge after hematopoietic stem cell transplantation [1]. In
transplant recipients, reactivation of herpes viruses, especially of the human …

Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjects

R Gil-Bescós, A Ostiz, S Zalba, I Tamayo… - Life Science …, 2023 - life-science-alliance.org
The development of new therapies for COVID-19 high-risk patients remains necessary to
prevent additional deaths. Here, we studied the phenotypical and functional characteristics …

Engineered HCMV‐infected APCs enable the identification of new immunodominant HLA‐restricted epitopes of anti‐HCMV T‐cell immunity

MM Santamorena, S Tischer‐Zimmermann… - HLA, 2024 - Wiley Online Library
Complications due to HCMV infection or reactivation remain a challenging clinical problem
in immunocompromised patients, mainly due to insufficient or absent T‐cell functionality …

Pathogen-specific T cells beyond CMV, EBV and adenovirus

W Jiang, B Withers, G Sutrave, LE Clancy… - Current Hematologic …, 2019 - Springer
Abstract Purpose of Review Infectious diseases contribute significantly to morbidity and
mortality in recipients of allogeneic haematopoietic stem cell transplantation (aHSCT) …

[HTML][HTML] High-intensity interval training in allogeneic adoptive T-cell immunotherapy–a big HIT?

NC Heinemann, S Tischer-Zimmermann… - Journal of Translational …, 2020 - Springer
Background Adoptive transfer of virus-specific T cells (VSTs) represents a prophylactic and
curative approach for opportunistic viral infections and reactivations after transplantation …

[HTML][HTML] Inhibition of heme oxygenase-1 activity enhances wilms tumor-1-Specific T-cell responses in cancer immunotherapy

DA Schillingmann, SB Riese, V Vijayan… - International Journal of …, 2019 - mdpi.com
Wilms tumor protein-1 (WT1) is an attractive target for adoptive T-cell therapy due to its
expression in solid tumors and hematologic malignancies. However, T cells recognizing …