Within the era of molecularly targeted anticancer agents, it has become increasingly
important to provide proof of mechanism as early on as possible in the drug development …

Purpose To determine the safety, pharmacokinetics (PK), and maximum-tolerated dose
(MTD) up to a prespecified target dose of dulanermin in combination with paclitaxel …

Serological cell death biomarkers and circulating tumor cells (CTCs) have potential uses as
tools for pharmacodynamic blood-based assays and their subsequent application to early …

Apoptosis or programmed cell death is a key mechanism to control tissue homeostasis, for
example, in the hematopoietic system. Thus, resistance to apoptosis can contribute to the …

Increased expression of antiapoptotic Bcl-2 proteins confers therapeutic resistance in
various cancer types. Targeting Bcl-2 proteins by small molecules or activating alternative …

Novel anticancer drugs targeting key apoptosis regulators have been developed and are
undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug …

Evasion of apoptosis is a hallmark of human cancers, for example in hematological
malignancies. Apoptosis is an intrinsic cell death program that is crucial to maintain tissue …

Tetrandrine is known to exert antitumor effect, however, little is known about its effect on
nasopharyngeal carcinoma cells. In this study, we tested tetrandrine-induced apoptosis and …

Evading apoptosis is pivotal in both of carcinogenesis and resistance to anticancer therapy.
We investigated the molecules and pathways of apoptosis evasion in human hepatoma cells …

Background: It is well established that mutations in the BRCA1 gene are a major risk factor
for breast cancer. Induction of cancer cell death and inhibition of survival are the main …