AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

[HTML][HTML] Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and non-viral hepatocarcinoma: Pathophysiological mechanisms and new therapeutic strategies

E Vetrano, L Rinaldi, A Mormone, C Giorgione… - Biomedicines, 2023 - mdpi.com
In recent years, the incidence of non-viral hepatocellular carcinoma (HCC) has increased
dramatically, which is probably related to the increased prevalence of metabolic syndrome …

[HTML][HTML] Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: current status and therapeutic targets

Y Chen, W Wang, MP Morgan, T Robson… - Frontiers in …, 2023 - frontiersin.org
Obesity is a global epidemic and overwhelming evidence indicates that it is a risk factor for
numerous cancers, including hepatocellular carcinoma (HCC), the third leading cause of …

[HTML][HTML] MAFLD: An optimal framework for understanding liver cancer phenotypes

H Crane, C Gofton, A Sharma, J George - Journal of Gastroenterology, 2023 - Springer
Hepatocellular carcinoma has a substantial global mortality burden which is rising despite
advancements in tackling the traditional viral risk factors. Metabolic (dysfunction) associated …

SGLT2i reduces risk of developing HCC in patients with co-existing type 2 diabetes and hepatitis B infection: A territory-wide cohort study in Hong Kong

CH Lee, LY Mak, EHM Tang, DTW Lui, JHC Mak… - Hepatology, 2023 - journals.lww.com
SGLT2i reduces risk of developing HCC in patients with co-ex... : Hepatology SGLT2i reduces
risk of developing HCC in patients with co-existing type 2 diabetes and hepatitis B infection: A …

[HTML][HTML] Development and prognosis of hepatocellular carcinoma in patients with diabetes

T Nakatsuka, R Tateishi - Clinical and Molecular Hepatology, 2023 - ncbi.nlm.nih.gov
The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been
increasing worldwide during the last few decades, in the context of an increasing prevalence …

AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway

Y Cheng, Z Zhang, P Gao, H Lai, W Zhong… - EMBO Molecular …, 2023 - embopress.org
Obesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the
underlying mechanisms are yet to be elucidated. Adeno‐associated virus (AAV) frequently …

Lower risks of cirrhosis and hepatocellular carcinoma with GLP‐1RAs in type 2 diabetes: A nationwide cohort study using target trial emulation framework

CT Yang, WY Yao, CY Yang, ZY Peng… - Journal of Internal …, 2024 - Wiley Online Library
Background To assess the association of cirrhosis and hepatocellular carcinoma (HCC) with
the use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) versus long‐acting …

Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook

A Jaffe, TH Taddei, EG Giannini… - Liver …, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a common complication in patients with chronic liver
disease and leads to significant morbidity and mortality. Liver disease and liver cancer are …

Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease?

M Huttasch, M Roden, S Kahl - Metabolism, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD) closely associates with
obesity and type 2 diabetes. Lifestyle intervention and bariatric surgery aiming at substantial …