Mechanism of anosmia caused by symptoms of COVID-19 and emerging treatments

R Najafloo, J Majidi, A Asghari… - ACS Chemical …, 2021 - ACS Publications
The occurrence of anosmia, the loss or change in sense of smell, is one of the most common
symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses …

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

GD De Melo, F Lazarini, S Levallois… - Science translational …, 2021 - science.org
Whereas recent investigations have revealed viral, inflammatory, and vascular factors
involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung …

Interventions for the prevention of persistent post‐COVID‐19 olfactory dysfunction

KE Webster, L O'Byrne, S MacKeith… - Cochrane Database …, 2022 - cochranelibrary.com
Background Loss of olfactory function is well recognised as a symptom of COVID‐19
infection, and the pandemic has resulted in a large number of individuals with abnormalities …

Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional study

M Maamar, A Artime, E Pariente, P Fierro… - Current Medical …, 2022 - Taylor & Francis
Abstract Objective Post-COVID syndrome (PCS) is a poorly known entity. An underlying
chronic, low-grade inflammation (LGI) has been theorized as a pathophysiological …

[PDF][PDF] Six month follow-up of self-reported loss of smell during the COVID-19 pandemic

C Hopkins, P Surda, LA Vaira, JR Lechien, M Safarian… - Rhinology, 2021 - academia.edu
Introduction: Loss of smell and taste is now recognised as amongst the most common
symptoms of COVID-19 and the best predictor of COVID-19 positivity. Long term outcomes …

Sociodemographic characteristics and comorbidities of patients with long COVID and persistent olfactory dysfunction

ACM Paranhos, ÁRN Dias, LCM da Silva… - JAMA Network …, 2022 - jamanetwork.com
Importance Determining the characteristics, type, and severity of olfactory dysfunction in
patients with long COVID is important for the prognosis and potential treatment of the …

More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with …

C Hopkins, JR Lechien, S Saussez - Medical hypotheses, 2021 - Elsevier
Three mechanisms have been proposed to account for COVID-19 associated olfactory
dysfunction; obstruction of the olfactory cleft; epithelial injury and infection of the …

Brain metabolic correlates of persistent olfactory dysfunction after SARS-Cov2 infection

MI Donegani, A Miceli, M Pardini, M Bauckneht… - Biomedicines, 2021 - mdpi.com
We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory
dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [18F] …

Pathogenesis of olfactory disorders in COVID-19

L Ziuzia-Januszewska, M Januszewski - Brain sciences, 2022 - mdpi.com
Since the outbreak of the SARS-CoV-2 pandemic, olfactory disorders have been reported as
a frequent symptom of COVID-19; however, its pathogenesis is still debated. The aim of this …

Modified olfactory training is an effective treatment method for COVID‐19 induced parosmia

A Altundag, E Yilmaz, MC Kesimli - The Laryngoscope, 2022 - Wiley Online Library
Objectives Coronavirus disease (COVID‐19) infection often causes olfactory dysfunction
and parosmia may occur in some patients with olfactory dysfunction. In this study, we …