[HTML][HTML] Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management

B Singh, CM Day, S Abdella, S Garg - Journal of Controlled Release, 2024 - Elsevier
Abstract Alzheimer's disease (AD), is a neurodegenerative disorder that escalates with time,
exerting a significant impact on physical and mental health and leading to death. The …

Current state and opportunities with long-acting injectables: industry perspectives from the innovation and quality consortium “long-acting injectables” working group

A Bauer, P Berben, SS Chakravarthi… - Pharmaceutical …, 2023 - Springer
Long-acting injectable (LAI) formulations can provide several advantages over the more
traditional oral formulation as drug product opportunities. LAI formulations can achieve …

Oral drug delivery systems applied to launched products: value for the patients and industrial considerations

T Yoshida, H Kojima - Molecular Pharmaceutics, 2023 - ACS Publications
Drug delivery systems (DDS) control the amount, rate, and site of administration of drug
substances in the body as well as their release and ADME (absorption, distribution …

Polyester-based long acting injectables: advancements in molecular dynamics simulation and technological insights

NG Kotla, A Pandey, YV Kumar, F Ramazani… - Drug discovery today, 2023 - Elsevier
Highlights•Polyesters including poly (lactic-co-glycolic acid)(PLGA) are promising polymers
for long-acting injectable (LAI) drug delivery. LAIs release the active pharmaceutical …

Role of modeling and simulation in preclinical and clinical long-acting injectable drug development

M Siemons, B Schroyen, N Darville, N Goyal - The AAPS Journal, 2023 - Springer
Innovations in the field of long-acting injectable drug development are increasingly being
reported. More advanced in vitro and in vivo characterization can improve our …

Long-acting injectable aqueous suspensions—summary from an AAPS Workshop

R Holm, RW Lee, J Glassco, N DiFranco, Q Bao… - The AAPS Journal, 2023 - Springer
Through many years of clinical application of long-acting injectables, there is clear proof that
this type of formulation does not just provide the patient with convenience, but more …

Polymers and their engineered analogues for ocular drug delivery: Enhancing therapeutic precision

A Biswas, S Kumar, AD Choudhury, AC Bisen… - …, 2024 - Wiley Online Library
Ocular drug delivery is constrained by anatomical and physiological barriers, necessitating
innovative solutions for effective therapy. Natural polymers like hyaluronic acid, chitosan …

Long acting injectables for the treatment of prostate cancer

D Modi, MS Hussain, S Ainampudi… - Journal of Drug Delivery …, 2024 - Elsevier
Prostate cancer ranks as one of the most diagnosed and challenging malignancies affecting
individuals worldwide. For hormone-dependent prostate cancer treatment Gonadotropin …

Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells

MG Fuster, J Wang, O Fandiño, G Víllora… - Molecular …, 2024 - ACS Publications
The nanocrystal (NC) technology has become one of the most commonly used strategies for
the formulation of poorly soluble actives. Given their large specific surface, NCs are mainly …

Patient-Centric Long-Acting Injectable and Implantable Platforms─ An Industrial Perspective

S Alidori, R Subramanian, R Holm - Molecular Pharmaceutics, 2024 - ACS Publications
The increasing focus on patient centricity in the pharmaceutical industry over the past
decade and the changing healthcare landscape, driven by factors such as increased access …