Osteoarthritis (OA) is a set of overlapping conditions involving the loss of articular cartilage
and changes to the underlying subchondral bone; ultimately, the structure and function of an …

Background A chronic progressive degenerative joint disease, such as osteoarthritis (OA) is
positively related to age. The medical economy is facing a major burden, because of the …

Skeletal tissues are uniquely important for anthropological research—from comparative
skeletal anatomy that informs primate evolutionary theories to bioarchaeology and forensics …

Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

Objective Epigenetic factors, such as DNA methylation, play an influential role in the
development of the degenerative joint disease osteoarthritis (OA). These molecular …

Whengeneexpressionprofileisusedforgene…, theprobeonthechipcanemitfluorescencewith…
wavelengths. Undertheactionofconfocallaserscanner …

Background: The aim of this study was to use the latest BeadChip technology to obtain a
genome-wide DNA methylation profile for cartilage from patients with primary knee …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information-containing factors, other …

Computer and data scientists are increasingly tasked with analyzing data growing at
unprecedented rates. These data frequently involve a high level of dimensionality. In this …

We are currently experiencing an explosive growth in data collection technology that
threatens to dwarf the commensurate gains in computational power predicted by Moore's …