Knee osteoarthritis (OA) is a leading cause of chronic disability worldwide, but no diagnostic
or prognostic biomarkers are available. Increasing evidence supports epigenetic …

The development of disease-modifying pharmacologic therapy for osteoarthritis currently
faces major obstacles largely because the pathogenetic mechanisms for the development of …

Osteoarthritis (OA) is the most common irreversible chronic joint dysfunction disease, which
is pathologically characterized by disturbance of articular cartilage homeostasis leading to …

Skeletal dysplasias are Mendelian disorders with a prevalence of approximatively 1 in every
5000 individuals and can usually be diagnosed based on clinical and radiological findings …

Osteoarthritis (OA) is a common type of arthritis, which may cause pain and disability.
Alterations in gene expression and DNA methylation have been proven to be associated …

Osteoarthritis is one of the most prevalent chronic joint diseases for middle-aged and elderly
people. But in recent years, the number of young people suffering from the disease …

Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …

Patients at different ages have different rates of cell development and metabolisms. As a
result, age should be an essential part of how a disease diagnosis model is trained and …

DNA methylation, a critical epigenetic mechanism, plays an important role in governing
gene expressions during biological processes such as aging, which is well known to be …

Valgus-varus deformity (VVD) is a common leg bone problem in broilers that causes serious
economic losses to the breeding industry. The genetic aetiology of VVD is not clear, which …