Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable
environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen …

Epidemiological studies have found strong associations between air pollution and
respiratory effects including development and/or exacerbation of asthma and chronic …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states,
eg, in the aging process and age-related diseases. IDO1 enzyme catabolizes L-tryptophan …

Air pollution is the most important environmental risk factor for disease and premature death,
and exposure to combustion particles from vehicles is a major contributor. Human …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …

The aryl hydrocarbon receptor (AhR) is a ligand‑activated transcription factor originally
isolated and characterized as the dioxin or xenobiotic receptor. With the discovery of …

Exposures to fine particulate matter (PM 1) have been associated with health impacts, but
the understanding of the PM 1 concentration-response (PM 1-CR) relationships, especially …

Air pollution is a major public health concern worldwide. Exposure to fine particulate matter
(PM2. 5) is closely associated with cardiovascular diseases. However, the effect of PM2. 5 …

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that …

Epidemiological studies have shown that cardiovascular diseases caused by PM 2.5
pollution account for the second death rate in China. Polycyclic aromatic hydrocarbons …