The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Since immune cells represent a large fraction of the TME, they play a key role in …

Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …

Simple Summary Triple-negative breast cancer is a life-threatening disease, even when
identified at early stages. Recent advances have allowed the improvement of life expectancy …

Pancreatic cancer has a dismal prognosis, and treatment options for patients with locally
advanced or metastatic disease are limited. Early tumor progression after standard chemo …

Simple Summary Patients with cancer of the digestive system or ovarian cancer are at risk of
developing peritoneal metastases (PM). In some patients with PM, surgery followed by …

Background Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment
(TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 …

Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-
grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal …

Simple Summary Regional immunotherapy is a promising approach for treating peritoneal
carcinomatosis gastric/gastroesophageal junction cancer (GC-PC) patients. This review …

Despite remarkable progress during the past decade, eradication of established tumors by
targeted cancer therapy and cancer immunotherapy remains an uphill task. Herein, we …

Abstract Purpose Prostaglandin E2 (PGE2), a product of cyclooxygenase (COX) pathway of
arachidonic acid, exerts inhibitory impacts on dendritic cell (DC) activity to repress anti-tumor …