Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Introduction The recent global outbreak of coronavirus disease 2019 (COVID-19) has
become a pandemic with a lot of sufferers. Excessive inflammation, exaggerated immune …

ABSTRACT Introduction Alpha1-blockers (AB) are the first-line monotherapy for lower
urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors are the first-line …

Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5‐I), is primarily used for treating
erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate …

Introduction Despite the ever-increasing occurrences of the coronavirus disease (COVID-19)
cases around the world, very few medications have been validated in the clinical trials to …

This cohort study aimed to assess the effect of the mode of delivery on female sexual
function (FSF) after childbirth. Out of 256 primiparous women, 200 subjects that completed …

Introduction Phosphodiesterase type 5 inhibitors (PDE5i), the most widely used drugs for
erectile dysfunction, could also improve lower urinary tract symptoms, essentially due to …

Aging is associated with a deterioration of cognitive performance and with increased risk of
neurodegenerative disorders. In the present study we tested whether the specific …

Background Pregnancy is a special period in the life of women characterised by physical,
hormonal and psychological changes that, in conjugation with social and cultural influences …

Since the discovery of phosphodiesterase-5 (PDE5) enzyme overexpression in the central
nervous system (CNS) malignancies, investigations have explored the potential capacity of …