In this study we tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and
vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces …

Changes in renal hemodynamics have a major impact on blood pressure (BP). Angiotensin
(Ang) II has been shown to induce vascular dysfunction by interacting with …

ABSTRACT Background Nowadays, Oral phosphodiesterase type 5 inhibitors (PDE5Is) are
widely used for the treatment of erectile dysfunction (ED). However, these drugs have …

Introduction It has been shown that phosphodiesterase type 5 (PDE5) inhibitors preserve
smooth muscle (SM) content and ameliorate the fibrotic degeneration normally seen in the …

Abstract PDE5 inhibitors (PDE5i) are widely known as treatment for erectile dysfunction
(ED). This favorable action has emerged as a “side effect” from pioneering studies when …

Background Phosphodiesterase type 5 inhibitors restore nitric oxide signaling, that plays a
significant role in erectile function, and appears to counteract insulin resistance in animal …

The nonspecific PDE inhibitors, particularly the methylxanthines: caffeine, pentoxifylline
(PTX), and theophylline, are known to stimulate sperm motility in vitro and have been used …

Background: Severeal in vivo and in vitro studies have been carried out in order to evaluate
the efficacy of long-term treatment with phosphodiesterase type-5 (PDE5) inhibitors (PDE5i) …

Background Phosphodiesterase type 5 inhibitors (PDE5Is), due to their efficacy and
tolerable profile for more than 2 decades, are considered a good addition to the available …

Penile erection (PE) is a hemodynamic event that results from a neuroendocrine process,
and it is influenced by the cardiovascular status of the patient. However, it may also …