NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive
clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial …

Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …

B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may
be tissue-resident cells. Here we show that pulmonary influenza infection elicited lung …

Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery
of useful antibodies for therapeutic or research purposes. We present a method for high …

Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice
and humans; however, their contribution to recall responses has not been defined. Here, we …

B cells within germinal centers (GCs) enter cycles of antibody affinity maturation or exit the
GC as memory cells or plasma cells. Here, we examined the contribution of interleukin (IL)-4 …

The structural integrity of vaccine antigens is critical to the generation of protective antibody
responses, but the impact of protease activity on vaccination in vivo is poorly understood …