The endocannabinoid system in glial cells and their profitable interactions to treat epilepsy: Evidence from animal models
J Egaña-Huguet, E Soria-Gómez… - International Journal of …, 2021 - mdpi.com
Epilepsy is one of the most common neurological conditions. Yearly, five million people are
diagnosed with epileptic-related disorders. The neuroprotective and therapeutic effect of …
diagnosed with epileptic-related disorders. The neuroprotective and therapeutic effect of …
Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11. 2 duplication
Adolescent cannabis use increases the risk for cognitive impairments and psychiatric
disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and …
disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and …
Subsynaptic distribution, lipid raft targeting and G protein-dependent signalling of the type 1 cannabinoid receptor in synaptosomes from the mouse hippocampus and …
M Saumell-Esnaola, S Barrondo, G García del Caño… - Molecules, 2021 - mdpi.com
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in
glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue …
glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue …
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease
I Terradillos, I Bonilla‐Del Río, N Puente, M Serrano… - Glia, 2023 - Wiley Online Library
The alteration of the endocannabinoid tone usually associates with changes in the
expression and/or function of the cannabinoid CB1 receptor. In Alzheimer's disease (AD) …
expression and/or function of the cannabinoid CB1 receptor. In Alzheimer's disease (AD) …
Fit-for-purpose based testing and validation of antibodies to amino-and carboxy-terminal domains of cannabinoid receptor 1
L Echeazarra, G García del Caño, S Barrondo… - Histochemistry and cell …, 2021 - Springer
Specific and selective anti-CB1 antibodies are among the most powerful research tools to
unravel the complex biological processes mediated by the CB1 receptor in both …
unravel the complex biological processes mediated by the CB1 receptor in both …
Endocannabinoid 2-arachidonoylglycerol levels in the anterior cingulate cortex, caudate putamen, nucleus accumbens, and piriform cortex were upregulated by …
Endocannabinoid 2-arachidonoylglycerol (2-AG) has been implicated in habituation to
stress, and its augmentation reduces stress-induced anxiety-like behavior. Chronic restraint …
stress, and its augmentation reduces stress-induced anxiety-like behavior. Chronic restraint …
Lack of the transient receptor potential vanilloid 1 shifts cannabinoid-dependent excitatory synaptic plasticity in the dentate gyrus of the mouse brain hippocampus
J Egaña-Huguet, M Saumell-Esnaola… - Frontiers in …, 2021 - frontiersin.org
The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the
brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines …
brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines …
Environmental enrichment rescues endocannabinoid-dependent synaptic plasticity lost in young adult male mice after ethanol exposure during adolescence
I Rico-Barrio, S Peñasco, L Lekunberri, M Serrano… - Biomedicines, 2021 - mdpi.com
Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH)
consumption can have cognitive sequelae later in life. Remarkably, an enriched …
consumption can have cognitive sequelae later in life. Remarkably, an enriched …
Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative …
M Saumell-Esnaola, A Elejaga-Jimeno… - Microbial Cell …, 2022 - Springer
Background Replacement of radioligand binding assays with antibody-antigen interaction-
based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels …
based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels …
Up-regulation of CB1 cannabinoid receptors located at glutamatergic terminals in the medial prefrontal cortex of the obese Zucker rat
L Echeazarra, S Barrondo… - Frontiers in …, 2022 - frontiersin.org
The present study describes a detailed neuroanatomical distribution map of the cannabinoid
type 1 (CB1) receptor, along with the biochemical characterization of the expression and …
type 1 (CB1) receptor, along with the biochemical characterization of the expression and …