The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics
analytic tools and access to depositories of curated data relevant to immune reactions and …
analytic tools and access to depositories of curated data relevant to immune reactions and …
Tumor neoantigens: building a framework for personalized cancer immunotherapy
It is now well established that the immune system can recognize developing cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design
Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …
specialized immune cells, then initiate an immune response. Computational prediction of the …
Improved methods for predicting peptide binding affinity to MHC class II molecules
Major histocompatibility complex class II (MHC‐II) molecules are expressed on the surface
of professional antigen‐presenting cells where they display peptides to T helper cells, which …
of professional antigen‐presenting cells where they display peptides to T helper cells, which …
T cell epitope predictions
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
Peptide-based vaccines for tuberculosis
W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
TepiTool: a pipeline for computational prediction of T cell epitope candidates
Computational prediction of T cell epitope candidates is currently being used in several
applications including vaccine discovery studies, development of diagnostics, and removal …
applications including vaccine discovery studies, development of diagnostics, and removal …
Machine learning techniques for the prediction of B-cell and T-cell epitopes as potential vaccine targets with a specific focus on SARS-CoV-2 pathogen: A review
SNH Bukhari, A Jain, E Haq, A Mehbodniya, J Webber - Pathogens, 2022 - mdpi.com
The only part of an antigen (a protein molecule found on the surface of a pathogen) that is
composed of epitopes specific to T and B cells is recognized by the human immune system …
composed of epitopes specific to T and B cells is recognized by the human immune system …
Immunoinformatics-aided design of a peptide based multiepitope vaccine targeting glycoproteins and membrane proteins against monkeypox virus
Monkeypox is a self-limiting zoonotic viral disease and causes smallpox-like symptoms. The
disease has a case fatality ratio of 3–6% and, recently, a multi-country outbreak of the …
disease has a case fatality ratio of 3–6% and, recently, a multi-country outbreak of the …