Investigational drug therapies in phase I and phase II clinical trials for alcohol use disorders
LC Walker, AJ Lawrence - Expert Opinion on Investigational Drugs, 2018 - Taylor & Francis
Introduction: Alcohol use disorder (AUD) is a complex psychiatric condition characterized by
craving, compulsive seeking, loss of control of alcohol consumption as well as the …
craving, compulsive seeking, loss of control of alcohol consumption as well as the …
Barriers and breakthroughs in targeting the oxytocin system to treat alcohol use disorder
AE Ryabinin, Y Zhang - Frontiers in Psychiatry, 2022 - frontiersin.org
Development of better treatments for alcohol use disorder (AUD) is urgently needed. One
promising opportunity for this development is the potential of targeting the oxytocin peptide …
promising opportunity for this development is the potential of targeting the oxytocin peptide …
C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and …
L Pasquetta, E Ferreyra, A Wille-Bille, RM Pautassi… - …, 2024 - Springer
Objectives To investigate if SM and BP offspring infant mice exhibit differential sensitivity to
ethanol-induced locomotor activity and differential activity patterns in brain areas related to …
ethanol-induced locomotor activity and differential activity patterns in brain areas related to …
Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice
Abstract Introduction The oxytocin (Oxt) system, while typically associated with the neural
regulation of social behaviors, also plays a role in an individual's vulnerability to develop …
regulation of social behaviors, also plays a role in an individual's vulnerability to develop …
Relationship between dietary intake and behaviors with oxytocin: a systematic review of studies in adults
JA Skinner, ML Garg, CV Dayas, S Fenton… - Nutrition …, 2018 - academic.oup.com
Context Oxytocin plays an important hormonal role in the regulation of feeding and energy
intake. Objective The aims of this review were to 1) determine the effects of dietary …
intake. Objective The aims of this review were to 1) determine the effects of dietary …
Investigational drugs for alcohol use disorders: a review of preclinical data
SS Ch'Ng, AJ Lawrence - Expert opinion on investigational drugs, 2018 - Taylor & Francis
ABSTRACT Introduction: Alcohol use disorders (AUDs) are one of the leading causes of
preventable death in the developed world. In the US, only three FDA-approved …
preventable death in the developed world. In the US, only three FDA-approved …
Intranasal oxytocin does not modulate responses to alcohol in social drinkers
Background Preclinical and clinical evidence suggest that the neuropeptide oxytocin may be
of value in treating alcohol use disorder, by either reducing the rewarding effects of alcohol …
of value in treating alcohol use disorder, by either reducing the rewarding effects of alcohol …
[HTML][HTML] Methylation of the Oxytocin, Oxytocin Receptor, and Vasopressin Gene Promoters in Tobacco Use Disorder during Cessation
PJ Proskynitopoulos, S Bleich, MAN Muschler… - …, 2024 - karger.com
Introduction: Vasopressin (AVP) and oxytocin (OT) exert sex-specific effects on social pair
bonding and stress reactions while also influencing craving in substance use disorders. In …
bonding and stress reactions while also influencing craving in substance use disorders. In …
Regulation of social behaviors by p-Stat3 via oxytocin and its receptor in the nucleus accumbens of male Brandt's voles (Lasiopodomys brandtii)
Social behavior plays a significant role in the formation of social structure and population
regulation in both animals and humans. Oxytocin (OXT) and its receptor (OXTR) are well …
regulation in both animals and humans. Oxytocin (OXT) and its receptor (OXTR) are well …
Bulleyaconitine A inhibits morphine-induced withdrawal symptoms, conditioned place preference, and locomotor sensitization via microglial dynorphin A expression
MJ Zhao, MY Wang, L Ma, KA Ahmad… - Frontiers in …, 2021 - frontiersin.org
Bulleyaconitine A (BAA), a C19-diterpenoid alkaloid, has been prescribed as a nonnarcotic
analgesic to treat chronic pain over four decades in China. The present study investigated its …
analgesic to treat chronic pain over four decades in China. The present study investigated its …