Investigational drug therapies in phase I and phase II clinical trials for alcohol use disorders

LC Walker, AJ Lawrence - Expert Opinion on Investigational Drugs, 2018 - Taylor & Francis
Introduction: Alcohol use disorder (AUD) is a complex psychiatric condition characterized by
craving, compulsive seeking, loss of control of alcohol consumption as well as the …

Barriers and breakthroughs in targeting the oxytocin system to treat alcohol use disorder

AE Ryabinin, Y Zhang - Frontiers in Psychiatry, 2022 - frontiersin.org
Development of better treatments for alcohol use disorder (AUD) is urgently needed. One
promising opportunity for this development is the potential of targeting the oxytocin peptide …

C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and …

L Pasquetta, E Ferreyra, A Wille-Bille, RM Pautassi… - …, 2024 - Springer
Objectives To investigate if SM and BP offspring infant mice exhibit differential sensitivity to
ethanol-induced locomotor activity and differential activity patterns in brain areas related to …

Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice

KM Rodriguez, BL Smith, HK Caldwell - Brain and Behavior, 2020 - Wiley Online Library
Abstract Introduction The oxytocin (Oxt) system, while typically associated with the neural
regulation of social behaviors, also plays a role in an individual's vulnerability to develop …

Relationship between dietary intake and behaviors with oxytocin: a systematic review of studies in adults

JA Skinner, ML Garg, CV Dayas, S Fenton… - Nutrition …, 2018 - academic.oup.com
Context Oxytocin plays an important hormonal role in the regulation of feeding and energy
intake. Objective The aims of this review were to 1) determine the effects of dietary …

Investigational drugs for alcohol use disorders: a review of preclinical data

SS Ch'Ng, AJ Lawrence - Expert opinion on investigational drugs, 2018 - Taylor & Francis
ABSTRACT Introduction: Alcohol use disorders (AUDs) are one of the leading causes of
preventable death in the developed world. In the US, only three FDA-approved …

Intranasal oxytocin does not modulate responses to alcohol in social drinkers

A Vena, A King, R Lee, H de Wit - Alcoholism: Clinical and …, 2018 - Wiley Online Library
Background Preclinical and clinical evidence suggest that the neuropeptide oxytocin may be
of value in treating alcohol use disorder, by either reducing the rewarding effects of alcohol …

[HTML][HTML] Methylation of the Oxytocin, Oxytocin Receptor, and Vasopressin Gene Promoters in Tobacco Use Disorder during Cessation

PJ Proskynitopoulos, S Bleich, MAN Muschler… - …, 2024 - karger.com
Introduction: Vasopressin (AVP) and oxytocin (OT) exert sex-specific effects on social pair
bonding and stress reactions while also influencing craving in substance use disorders. In …

Regulation of social behaviors by p-Stat3 via oxytocin and its receptor in the nucleus accumbens of male Brandt's voles (Lasiopodomys brandtii)

L Yan, X Sun, Z Wang, M Song, Z Zhang - Hormones and Behavior, 2020 - Elsevier
Social behavior plays a significant role in the formation of social structure and population
regulation in both animals and humans. Oxytocin (OXT) and its receptor (OXTR) are well …

Bulleyaconitine A inhibits morphine-induced withdrawal symptoms, conditioned place preference, and locomotor sensitization via microglial dynorphin A expression

MJ Zhao, MY Wang, L Ma, KA Ahmad… - Frontiers in …, 2021 - frontiersin.org
Bulleyaconitine A (BAA), a C19-diterpenoid alkaloid, has been prescribed as a nonnarcotic
analgesic to treat chronic pain over four decades in China. The present study investigated its …