Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …

Germline loss-of-function mutations in the transcription factor signal transducer and activator
of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …

The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent
years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in …

Vasculitis of the medium and large arteries, most often presenting as giant cell arteritis
(GCA), is an infrequent, but potentially fatal, type of immune-mediated vascular disease. The …

Systemic immune-mediated diseases (SIDs) include autoimmune and autoinflammatory
diseases (AD) affecting at least two-organ systems. 1 Autoinflammatory diseases refer to a …

Signal Transducer and Activator of Transcription (STAT) 3 has recently emerged as a key
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …

Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

Th17 immunity in the gastrointestinal tract is regulated by the intestinal microbiota
composition, particularly the presence of segmented filamentous bacteria (sfb), but the role …