Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been
widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung …

Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed
throughout the human genome, both in coding and non-coding regions. Owing to their …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …

Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair
system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to …

More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …