Osteoporosis predisposes patients to spinal fragility fractures. Imaging plays a key role in the
diagnosis and prognostication of these osteoporotic vertebral fractures (OVF). However, the …

Imaging investigations are critical in the management of children with suspected and
confirmed osteopetrosis. In severe cases, imaging can provide rapid confirmation of the …

Osteoblast Wnt/β catenin signaling conditions skeletal development and health. Bone
formation is stimulated when on the osteoblast surface a Wnt binds to low density lipoprotein …

Wnt signaling is a key regulator of osteoblast differentiation and mineralization in humans
and animals, mediated by the canonical Wnt/β-catenin and noncanonical signaling …

Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by the
calcification and ossification of the ligaments of the cervical spine; in some cases, it may …

Background High bone mass (HBM, BMD Z-score≥+ 3.2) and cam morphology (bulging of
lateral femoral head) are associated with greater odds of prevalent radiographic hip …

Osteoporosis is the most prevalent bone condition in the ageing population. This systemic
disease is characterized by microarchitectural deterioration of bone, leading to increased …

The formation and maintenance of the gross structure and microarchitecture of the human
skeleton require the concerted functioning of a plethora of morphogenic signaling …

Environmental factors and genetic variation individually impact bone. However, it is not clear
how these factors interact to influence peak bone mass accrual. Here we tested whether …

Background The human lineage has undergone a postcranial skeleton gracilization (ie
lower bone mass and strength relative to body size) compared to other primates and archaic …