Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they
can die through programmed cell death upon the stimulation of specific signalling pathways …

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory
necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which
they reside. The activation of these proteins occurs via sequential programs, and much effort …

Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have
emerged as pleiotropic modulators of inflammatory responses that act either by directly …

Staphylococcus aureus is a prominent human pathogen capable of infecting a variety of host
species and tissue sites. This versatility stems from the pathogen's ability to secrete diverse …