5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

Abstract Serotonin (5-hydroxytryptamien, 5-HT) has been linked to emotional and
motivational aspects of human behavior, including anxiety, depression, impulsivity, etc …

Early-life stress is an established risk for the development of psychiatric disorders. Post-
weaning isolation rearing of rats produces lasting developmental changes in behavior and …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Serotonin (5-HT) plays an important role in the regulation of several basic functions of the
central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) …

Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many
physiological or pathophysiological processes including cognitive function. Seven distinct …

Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …

Alzheimer's disease (AD) has a complex and not-fully-understood etiology. Recently, the
serotonin receptor 5-HT6 emerged as a promising target for AD treatment; thus, here a new …

Despite the better understanding of the mechanisms underlying Alzheimer's Disease (AD)
and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been …