Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Abstract Transforming Growth Factor (TGF)-β is markedly induced and rapidly activated in
the infarcted myocardium. However, understanding of the exact role of TGF-β signaling in …

Background—Cardiac interstitial fibrosis plays an important role in the pathogenesis of
ischemic cardiomyopathy, contributing to systolic and diastolic dysfunction. We have …

Background—Using a resolution 1000-fold higher than prior studies, we studied (1) the
degree to which late gadolinium-enhancement (LGE) cardiac magnetic resonance tracks …

Preservation and development of life depend on the adequate segregation of sister
chromatids during mitosis and meiosis. This process is ensured by the cohesin multi-subunit …

Many have speculated that MRI signal characteristics can be used to identify regions of
heterogeneous infarct associated with an arrhythmogenic substrate; however, direct …

Hydrogen sulfide (H2S) is a gasotransmitter which regulates multiple cardiovascular
functions. However, the precise roles of H2S in modulating myocardial fibrosis in vivo and …

Cardiac fibroblasts (CF) not only modulate extracellular matrix (ECM) proteins homeostasis,
but also respond to chemical and mechanical signals. CF express a variety of receptors …

Background: Cardiac fibroblasts are a critical cell population responsible for myocardial
extracellular matrix homeostasis. Upon injury or pathological stimulation, these cells …

Background Cardiac fibrosis attributed to excessive deposition of extracellular matrix
proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and …