Caveolae, flask-like invaginations of the plasma membrane, were discovered nearly 60
years ago. Originally regarded as fixation artifacts of electron microscopy, the functional role …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Epithelial glucose transport is accomplished by Na+‐glucose co‐transporters, SGLT1 and
SGLT2. In the intestine, uptake of dietary glucose is for its majority mediated by SGLT1, and …

Caveolae are specialized plasma membrane subdomains with distinct lipid and protein
compositions, which play an essential role in cell physiology through regulation of trafficking …

We show here that the apposition of plasma membrane caveolae and mitochondria (first
noted in electron micrographs> 50 yr ago) and caveolae-mitochondria interaction regulates …

When considering which components of the cell are the most critical to function and
physiology, we naturally focus on the nucleus, the mitochondria that regulate energy and …

In adapting to disease and loss of tissue, the heart shows great phenotypic plasticity that
involves changes to its structure, composition and electrophysiology. Together with parallel …

The principal treatment strategy for patients with pulmonary artery hypertension (PAH) is the
use of medications targeting the pulmonary vasculature (1, 2). Despite several classes of …

Rationale: In heart failure, myofilament proteins display abnormal phosphorylation, which
contributes to contractile dysfunction. The mechanisms underlying the dysregulation of …